Apr 2, 2018 - Science and innovations
New substance with strong antitumor efficacy was synthesized in FEFU

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Researchers of Far East Federal University (FEFU) have obtained a new synthetic derivative of fascaplysin: biologically active substance from a sea sponge with antitumor properties. Biotests showed that the compound exceeds in 2-3 times the initial fascaplysin activity and can be used to improve anticancer drugs in the future. The results of the research have been published in the authoritative scientific journal Tetrahedron Letters.

“Fascaplysin is a unique compound. Among a wide range of its biological activity stands out the ability to selectively suppress the enzyme cyclin-dependent kinase 4 (CDK 4), which provides a rapid and uncontrolled division of cancer cells. We have obtained a new derivative of fascaplysin, tested it on cervical cancer cells and glandular leukemia. The results showed 2-3 times more activity than that of the original fascaplysin,” said Maxim Zhidkov, Associate Professor, Organic Chemistry Department, FEFU School of Natural Sciences.

The researcher added that the study also developed a method of synthesis of another substance related to fascaplysin: 6-oxofascaplysin. This compound was obtained for the first time from the well-known indigo dye.

“We are currently working on a methodology for obtaining a wide range of fascaplysin derivatives of a new type using computer simulation and molecular docking techniques. Our calculation analysis has shown that there is a high probability to find prospective candidates among them with the expressed antitumor and analgesic effect,” added Maxim Zhidkov.