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“Fascaplysin is a unique compound. Among a wide range of its biological activity stands out the ability to selectively suppress the enzyme cyclin-dependent kinase 4 (CDK 4), which provides a rapid and uncontrolled division of cancer cells. We have obtained a new derivative of fascaplysin, tested it on cervical cancer cells and glandular leukemia. The results showed 2-3 times more activity than that of the original fascaplysin,” said Maxim Zhidkov, Associate Professor, Organic Chemistry Department, FEFU School of Natural Sciences.
The researcher added that the study also developed a method of synthesis of another substance related to fascaplysin: 6-oxofascaplysin. This compound was obtained for the first time from the well-known indigo dye.
“We are currently working on a methodology for obtaining a wide range of fascaplysin derivatives of a new type using computer simulation and molecular docking techniques. Our calculation analysis has shown that there is a high probability to find prospective candidates among them with the expressed antitumor and analgesic effect,” added Maxim Zhidkov.