Vitaly A. Sorokin

Far Eastern Federal University, School of Biomedicine

English level: Fluent 

Programs: Cardio-vascular Surgery, Vascular Smooth Muscle Cell Biology

Programs for applicants: Cardio-vascular Surgery, Biology/Histology  

List of research projects of a potential advisor: 

Genetic and Protein marker as potential therapeutic and diagnostic targets to underline intercellular interaction and modulation of VSMC and vessel wall progenitor cells

List of research topics: 

3D vessel wall modulation (spheroid)

Next generation sequencing of isolated population of vessel wall cells 

10х system application to landscape vessel wall cellular profile in different cardio-vascular pathological conditions

Vessel wall immuno-biology

VSMC modulation with sncRNA

CRISPER technology as a tool to investigate genetic mechanisms behind VSMC modulation

Research highlights:

Cardiovascular disease leading cause of death in developed and countries including Russia Inflammation and  Results of intellectual activity:

Inflammation and pathological VSMC modulation are key mechanism in the development of atherosclerotic disease.

Decoding of genetic and epigenetic control of these processes could be potential solution.

Supervisor’s specific requirements:

· IHC

· DNA/RNA extraction, experience with qPCR, mass spectrometer, next-generation sequencing transfection, plasmid CRISPER

Publications:

Cardioplegia and myocardial protection in adult cardiac surgery: Current trends

Klyshko, N.K., Shchava, S.P., Furgal, A.A., (...), Goncharuk, R.A., Sorokin, V.A.

2020 Kardiologiya i Serdechno-Sosudistaya Khirurgiya

The interaction between 30b-5p miRNA and MBNL1 mRNA is involved in vascular smooth muscle cell differentiation in patients with coronary atherosclerosis  

Open Access Woo, C.C., Liu, W., Lin, X.Y., (...), Nookaew, I., Sorokin, V.

2020 International Journal of Molecular Sciences

Coronary artery bypass grafting in patients with low ejection fraction: What are the risk factors?  Vickneson, K., Chan, S.-P., Li, Y., (...), Caleb, M.G., Sorokin, V.

2019 Journal of Cardiovascular Surgery

Comparative evaluation of the constant and variable regimen of vacuum therapy in the treatment of postoperative sternomediastinitis in cardiac patients  

Wagon, A.A., Muratov, R.M., Shchava, S.P., (...), Mishchenko, E.P. Sorokin, V.A.

2019 Clinical and Experimental Surgery

Gene expression profile analysis of aortic vascular smooth muscle cells reveals upregulation of cadherin genes in myocardial infarction patients

Derda, A.A., Woo, C.C., Wongsurawat, T., (...), Kuznetsov, V.A., Sorokin, V.A.

2018 Physiological Genomics

A mysterious cause of constrictive pericarditis: the unfolding of the missing link

Open Access Arasaratnam, P., Kojodjojo, P., Sorokin, V.

2018 European heart journal cardiovascular Imaging 

Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction  

Open Access de Carvalho, L.P., Tan, S.H., Ow, G.-S., (...), Kuznetsov, V.A., Chan, M.Y. 2018 JACC: Basic to Translational Science 

Transcriptome alterations of vascular smooth muscle cells in the aortic wall of myocardial infarction patients   

Open Access Wongsurawat, T., Woo, C.C., Giannakakis, A., (...), Kuznetsov, V.A., Sorokin, V. 2018