Galina V. Reva

Far Eastern Federal University

Cell biology, cytology, histology, 06.06.01.

List of research projects

1. State assignment 2014/36 of 03.02.2014 -2016. Study of the mechanisms of carcinogenesis.

2. State task 17.5740 / 2017 / 6.7. -2019 Study of the mechanisms of carcinogenesis.

3. International Russian-Japanese grant (agreement No. 13-09-0602-m dated November 6, 2013; 2013-2016). Development of methods for early diagnosis of malignancy.

4. Research project 000000742 of 11/21/2020 "Regeneration of visceral and sensory systems in normal conditions, with malignancy and contamination of pathogens of socially significant infections" 11/16/2020 ⟶ 11/30/2022.

List of possible research topics

1. Development of a strategy for etiotropic treatment and prevention of glaucoma.

2. Fundamental and applied research of the mechanisms of regeneration of the organ of vision in health and disease.

3. Identification of new sources of stem cells and mechanisms of their differentiation for the development of a bioengineering strategy in the treatment of adentia and regenerative endodontics.

4. The role of stem and effector hematopoietic cells in carcinogenesis.

5. Research of mechanisms of glaucoma pathogenesis.

6. Fundamental and applied research of immune homeostasis of visceral systems in socially significant diseases of an infectious and non-infectious nature.

7. Development of forensic criteria for the diagnosis of age and early malignancy based on morphological and functional changes in skin structures.

8. Mechanisms of physiological and reparative regeneration in neurodegenerative processes in the structures of the eye and visual fields of the human brain.

9. Fundamental and applied research of the mechanisms of physiological and reparative regeneration of visceral and neurosensory systems in age-related aspects in health and socially significant diseases.

10. Development and improvement of methods for molecular genetic diagnosis of socially significant human diseases.

11. Mechanisms of carcinogenesis.

12. Development of methods of invasive and non-invasive cosmetology based on the study of scarring mechanisms.

13. Research of embryonic and postnatal stem cells niches of various body systems.

14. Mechanisms of angiogenesis in health and disease.

15. Neurodegenerative processes in the central nervous system and the organ of vision.

16. The role of migrants from the neural crest in the development of congenital pathology of the visceral and sensory systems.

17. Development of medical products for cosmetology and surgery.

Supervisor’s research interests 

All studies are performs exclusively on human material taken from patients with various pathologies and age groups, obtained during clinical assignment.
Development of morphological criteria and general patterns of cellular interactions violation in malignancy.
Study of the stem cell niches formation for tissues of various organs, the patterns of migration of cells from neural origin into the forming structures of organs, which are the key for the creation of scaffolds that correspond to the physiological needs of the human body.
Molecular genetics and immunohistochemical analysis of signaling pathways involved in the regulation, differentiation and specialization of cells.
Study the role of microbial contamination in malignancy of tissues in human body.
Search and study the key aspects for the pathogenesis of socially significant diseases, including multiple organ failure in SARS-COV-2.

Research highlights:

The program includes the study of physiological and reparative regeneration mechanisms of human visceral and sensory systems in health and disease. In particular, FEFU scientists are recognized as leading experts in Russia and abroad in the field of studying the structures of the human organ of vision and its prenatal development. There were successfully completed 17 projects, 8 of which are present data on the study of the structures of the human eye in health and disease. Within the framework of this program, leading morphologists are conducting innovative developments to create morphological criteria for the diagnosis of malignancy in the field of dermatology, obstetrics and gynecology, ophthalmology, gastroenterology, surgery, as evidenced by the registration of 12 patents for inventions in various medical fields.

Within the framework of the declared program, scientific work is being successfully carried out to establish the patterns of development of the organ of vision in onto- and phylogenesis, the sources of the rudiments of various structures development in the human eye are being clarified; the role of immunocytes in the formation and isolation of the structures of the human eye is revealed, the role of neuroglia in the formation of transparent media of the human eye is shown; on the basis of the discovery of the tissue organization of the vitreous body and phenotyping of vitreous hyalocytes with the solution of the issue of their histophysiological significance in the structure of the organ of vision, as well as the identification of microorganisms in the structure of the vitreum, an infectious concept of the pathogenesis of glaucoma, recognized in Russia and abroad, was put forward. The establishment of two sources of development of the human eye lens made it possible to identify new directions for the study of some congenital eye pathologies associated with impaired migration of neuroglia into the structures of transparent media.

Scientific data obtained by FEFU scientists are prerequisites for the emergence of new ways in the study of physiological regeneration in the structures of various organs and tissues, mechanisms of carcinogenesis, infectious diseases, transplantation, open up wide opportunities for the development of new strategies in the development of cellular technologies used in various fields of medical science. Within the framework of the program, data on the mechanisms of reparative regeneration in conditions of carcinogenesis, in case of burns, infectious, somatic and endocrine diseases of a person will be completed and supplemented. The model of carcinogenesis by R. Correa (1998) has been improved in the light of new data obtained by scientists from FEFU. Special attention in the research program is paid to the least studied issues of the development of regenerative medicine in gerontological groups of patients to reduce morbidity and mortality in age-related pathology.

The School of Medicine has highly qualified specialists – cell biologists and cytologists, doctors of medical sciences, possessing a complex of modern immunological and cytomorphological techniques that allow to study the mechanisms of cell regeneration, proliferation and differentiation. A scientific direction is being developed to study the mechanisms of reactivity of cells of innate and adaptive immunity in inflammatory diseases of infectious and non-infectious genesis.

Research work is planned within the framework of the experimental induction of the immune system functions by biologically active substances (BAS) from plant and marine organisms. Research within the framework of this program will make it possible to establish the molecular and cellular mechanisms of natural biologically active substances action on cells of innate and adaptive immunity, laying the foundation for the creation of original and effective drugs, dietary supplements and functional food products.

Studies of key signaling pathways of cells in local immune homeostasis, intercellular interactions that form a chain reaction of genetically determined biochemical mechanisms of a functional response are fundamental for any field of medicine. The implementation of the scientific program will be carried out by representatives and founders of scientific schools "Clinical morphology of visceral systems and the organ of vision", "Biological and medical approaches in the treatment of burn injury", which are considered leading scientists not only in Russia, their merits are recognized abroad.

An example of effective research is the fact that since 2013 at FEFU, within the framework of specialty 1.5.22 - cell biology (medical sciences), 7 dissertations have been completed, 4 – for a degree “Candidate of medical sciences” and 3 – for a degree “Doctor of medical sciences” have been defended and recognized by Russian academy of sciences. The successful implementation of the program is guaranteed by the experience of the research team that has completed dissertation research in the specialties of surgery, ophthalmology, dentistry, internal medicine, dermatovenerology and oncology, based on the analysis of data obtained by morphological and molecular genetic methods. At the present stage, there is no clinical research studies that do not touch upon the issues of cellular mechanisms in the pathogenesis of diseases and morphological changes in the structure involved in the pathological process. In the collective use laboratories of the FEFU Medical School, the study of the damaged structures regeneration of nervous tissue in people from different age groups is being carried out: the effect of pharmacological drugs on embryogenesis, teratogenicity, and regeneration processes in the age aspect is being investigated. There is experience in studying the possibility of using radiation therapy after targeted delivery of a nanoparticle to a tumor cells. FEFU guarantees financial, organizational and technical support for the activities of scientific groups. The university has the necessary premises and equipment for conducting scientific research. FEFU has technical capabilities for conducting distance classes and for holding online lectures using telecommunications network, which is confirmed by the positive experience of such broadcasts. FEFU is able and guarantees to ensure the work of young scientists at a high level.

Within the framework of the program, wide cooperation is planned both with leading research teams of universities in Russia, and international with universities in Europe, USA, and Japan. There will be involved in financing research projects pharmaceutical companies in Russia, Japan and Europe, as well as manufacturers of medical devices for use in various medical industries.

Supervisor’s specific requirements:

Applicant of the program must have a basic medical education. Possess the skills of analyzing scientific data on the Internet using the resources of the international databases WOS, SCOPUS, PUBMED. Have the skills to use a PC on various operating platforms, have a basic knowledge of the English language.

To have a wish:

To contribute to modern medical science, to increase the efficiency of modern diagnostics and treatment, to help reduce disability and mortality of the population with socially significant diseases, to obtain knowledge, skills and results that are in demand in practical health care.

Supervisor’s main publications

1. Wan, T.W COMPLETE CIRCULAR GENOME SEQUENCE OF SUCCESSFUL ST8/SCCMECIV COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (OC8) IN RUSSIA: ONE-MEGABASE GENOMIC INVERSION, IS256'S SPREAD, AND EVOLUTION OF RUSSIA ST8-IV./Wan T.W., Khokhlova O.E., Iwao Y., Reva I.V., Yamamoto T., Teng L.-J., Peryanova O.V., Higuchi W., Hung W.-C., Reva G.V., Singur O.A., Gostev V.V., Sidorenko S.V., Salmina A.B.//PLoS ONE. 2016. Т. 11. № 10. С. 164168. Q1, iF 3.372 (cit. score 3.207). SCOPUS

2. Protasova, I.N. MOLECULAR CHARACTERIZATION OF STREPTOCOCCUS PNEUMONIAE, PARTICULARLY SEROTYPE19A/ST320, WHICH EMERGED IN KRASNOYARSK, RUSSIA./Protasova I.N., Peryanova O.V., Yamamoto T., Wan T.W., Hung W.C., Iwao Y., Reva I.V., Teng L.J., Bakhareva N.V., Higuchi W., Yelistratova T.A., Ilyenkova N.A., Sokolovskaya Y.S., Martynova G.P., Reva G.V., Sidorenko S.V., Salmina A.B.//Microbiology and Immunology. 2017. Т. 61. № 9. С. 359-370. Q 3, iF 1.566. SCOPUS

3. Chaika, V. The toxic influence andbiodegradation of carbon nanofibers in freshwater invertebrates of the families Gammaridae,Ephemerellidae, and Chironomidae,/ Chaika, V, Pikula K, Vshivkova T, Zakharenko A, Reva G, DrozdovK, Vardavas AI, Stivaktakis PD, Nikolouzakis TK, Stratidakis AK, Kokkinakis MN, KalogerakiA, Burykina T, Sarigiannis DA, Kholodov A, Golokhvast K. //Toxicology Reports (2020), doi:https://doi.org/10.1016/j.toxrep.2020.07.011 Q2, iF 2,6 (cit. score 4.7). SCOPUS

4. Ignatiev, S. V. Morphological Evaluation of the Effectiveness of Immune-Stimulating Drugs in Patients with Diabetes and Removable Denture based on the Analysis of Biopsic Material Obtained from the Oral Mucosa./ Ignatiev S. V., Reva G.V., Pervov Y.Y., Kotsyurbii E. A., Yatsenko A. K.. //J. Environ. Treat. Tech. ISSN: 2309-1185. - 2020, Volume 8, Issue 1, Pages: 231-236. Impact: 4.25 Environmental Technology. 2-year Impact Factor 2.152 Q 4. SCOPUS

5. Reva, I. ERYTHROCYTES AS A TARGET OF SARS COV-2 IN PATHOGENESIS OF COVID-19./Reva I., Tatsuo Ya., Rasskazova M., Lemeshko T., Usov V., Krasnikov Yu., Fisenko A., Kotsyurbiy E., Tudakov V., Tsegolnik E., Oleksenko O., Korobkin A., Slabenko E., Shindina A., Gordzievskaya K., Furgal A., Reva G.//Archiv EuroMedica. 2020. Т. 10. № 3. С. 5-11. Q4, WOS, iF 3.03.

6. Reva, I. THE MECHANISM OF BLOOD COAGULATION IN COVID -19 PATHOGENESIS SARS-COV-2./Reva I., Tatsuo Ya., Usov V.V., Krasnikov Yu.A., Korobkin A., Slabenko E.V., Shindina A., Semiglasova V., Zhibanov P., Zotova D., Porva K., Dolganina Ya., Tuchina M.E., Gorbarenko R., Lemeshko T., Reva G.//Archiv EuroMedica. 2020. Т. 10. № 4. С. 9-12. Q4, WOS, iF 3.03.

Results of intellectual activity

5 monographs have been published: 3 are devoted to the development of the structures of the organ of vision; 2 - problems of dentistry.

12 patents for inventions were registered,

over the past 5 years:

1. Pat. RU 2652966C1. IPC A61F9 / 007, A61F9 / 00. Method of surgical treatment of post-traumatic enophthalmos / Odintsova I.A., Peshko A.P., Kulakov A.A., Albrandt K.F., Reva G.V., Brzhesky V.V., Reva I.V., Tolmachev V . E .; applicant and patentee FGA OU VO "FEFU" (RU). - No. 2017120054; app. 06/08/2017; publ. 05/03/2018. - Bul. No. 13. - 10 p.

2. Pat. RU 2653804C1 RU, IPC А61F9 / 00, А61F9 / 007. Method of surgical treatment of post-traumatic enophthalmos / Tolmachev V.E., Reva I.V., Reva G.V., Kulakov A.A., Peshko A.P., Odintsova I.A., Albrandt K.F .; applicant and patentee FGA OU VO "FEFU" (RU). - No. 2017120053; app. 06/08/2017; publ. 05/14/2018. - Bul. No. 14. - 6 p.

3. Pat.RU 2 700 680 C1. A method for the surgical treatment of skin melanoma. Reva G.V., Reva I.V., Usov V.V., Obydennikova T.N., Korobkin A.I., Gorkavaya A.Yu., Garmash R.A., Dey A.A., Shindina A D., Agapova T.M., Kotsyurbiy E.A., Fisenko A.Yu., Oleksenko O.M. 09/18/2019. - Bul. No. 26.- 2019. p.1-7. https://findpatent.ru/patent/270/2700680.html

4. Pat. RU 2 692 566 C1. Method for vacuum drainage of sternotomy wounds. Reva I.V., Furgal A.A., Reva G.V., Usov V.V., Obydennikova T.N., Klyshko N.K., Garmash A.I., Garmash R.A. 25.06.2019.- Bul. No. 18.- p.1-9.

5. Pat. RU 2662940C1 (51) IPC C12Q 1/68 (2006.01) RU 2 662 940 C1. Method for the diagnosis of chlamydia. / Reva I.V., Reva G.V., Odintsova I.A., Nikolaenko S.A., Khramova I.A., Pigolkin Yu, I. 20180731: applicant and patentee FGA OU VO "FEFU" (RU). - No. 2017134936; app. 10/05/2017; publ. 2018.07.31. - Bul. No. 22. - 6 p. 1-13.

6. Patent RU 2 708 241 C1 Method for examining oral fluid. / Reva I.V., Reva G.V., Tolmachev V.E., Voskanyan O.G., Baranovskaya I.A., Tsegolnik E, V., Tudakov V.S., Garmash A.I., Garmash R.A., Shindina A.D. // 05.12.2019. - Bul. No. 34.- p. 1-8.

7. Patent RU 2 619 387 C1. Wireless device for conjunctival microscopy. Bondar A / V., Gumovsky A. N., Nedobylskaya Yu. P., V., Reva I. V., Tulaev A. V. https://patentdb.ru/patent/2619387 05/15/2017. 05/15/2017. Bull. No. 14.- p. 1-8.

8. Patent RU 2 712 080 C1. A method of conducting a cytological study in the differential diagnosis of thyroid nodules. Reva G.V., Reva I.V., Grigoryan V.S., Kalinin I.O., Tudakov V.S., Tsegolnik E.V., Garmash A.I., Garmash R.A., Gordzievskaya Ya .O., Mozhilevskaya E.S., Nakorenok A.A., Puga D.P., Zudina A.V., Baranovskaya I.A. 24.05.2019. Bull. No. 3.- p. 1-7. https://yandex.ru/patents/doc/RU2712080C1_20200124

9. Patent RU 2 712 100 C1. A method for assessing the contamination of territories with pesticides by bioindication. Chaika V.V., Reva G.V., Reva I.V., Avtomonov E.A., Slabenko E.V. 24.01.2020. Bul. No. 3.

* proven tissue organization of the vitreous body of the human eye;

* established 2 sources of development of the human lens of the eye;

* Revealed the role of neuroglia in the development of transparent structures of the human eye;

* A fundamental platform has been developed for the implementation of cellular technologies in ophthalmology.

* Modified carcinogenesis scheme Correa (1998).

* Supplemented data on the sources of human teeth development.

* Studied the role of eosinophils in malignant polyps of the gastrointestinal tract.

* The role of erythrocytes in the pathogenesis of COVID-19 has been established.

* An archive of pathology of visceral and sensory systems of a person of various age groups has been created.