Oleg I. Pak

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Neurology and neurosurgery (,

Level of English language proficiency: advanced English.

list of research projects:

Development of a proteome-based biomedical technology of hematopoietic stem cells for the personalized therapy of human brain tumors (2014-2016 гг.),

Development of ways for personalizes therapy of glial brain tumors based on new technologies of oncoproteomics (2014-2016 гг.),

New ways for the targeted therapy of glioblastoma multiforme based on biomedical cell technologies (2017-2019 гг.),

Anticancer potential hematopoietic stem cells on the model human glioblastoma.

List of possible research topics:

New methods of drug delivery across the blood-brain barrier in CNS for cancer and injury,

New bionic and neuromodulation approaches in functional surgery of CNS cancer and injury,

New genomic -based methods for personalized therapy for CNS gliomas and carcinomas.

Supervisor’s research interests: new personalized approaches to the treatment of CNS cancer and injury.

Supervisor’s main publications:

• Personalized therapy and stem cell transplantation for proinflammatory modulation of cancer stem cells microenvironment in glioblastoma: Review International Review of Neurobiology 2020; 151, с. 67-98 IF Scopus 4,7
• Molecular determinants of the interaction between glioblastoma CD133+ cancer stem cells and the extracellular matrix International Review of Neurobiology 2020; 151, с. 155-169 IF Scopus 4,7
• Proteins of Wnt signaling pathway in cancer stem cells of human glioblastoma International Review of Neurobiology 2020; 151, с. 185-200 IF Scopus 4,7
• Pro-inflammatory modification of cancer cells microsurroundings increases the survival rates for rats with low differentiated malignant glioma of brain International Review of Neurobiology 2020 ;151, с. 253-279 IF Scopus 4,7
• Transforming growth factor-β mimics the key proteome properties of CD133− differentiated and CD133+ cancer stem cells in glioblastoma. International Review of Neurobiology 2020; 151, с. 219-242 IF Scopus 4,7

Results of intellectual activity: new biomedical and bionic approaches for treatment of gliomas and carcinomas of the human brain have been developed .